Replacement of missing central and lateral comes with unique challenges in achieving an aesthetic outcome. Bone and soft tissue deficiency along with availability of space can impact the treatment options: Type of bone grafting and soft tissue augmentation, space management through orthodontics, number of implants, type of transitional prosthesis, and approaches in both provisional and final restoration. In this debate-style presentation, we will discuss the restorative, surgical, and orthodontic principles when managing missing central and lateral incisors.